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In the 1990s the extracts of St. John's Wort were thought to be an antidepressant on the level of Prozac. I think that's been disproven, but Jack Sanders quotes an English herbalist, writing in 1799, who affirmed that the plant was effective in treating "maniacal disorders," and a 1911 source stating that the plant was thought to cure melancholy "if it is gathered on a Friday in the hour of Jupiter and worn away about the neck."
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